Author + information
- J. Brent Muhlestein,
- Jennifer Kammerer,
- Tami Bair,
- Kirk Knowlton,
- Viet T. Le,
- Jeffrey L. Anderson,
- Donald Lappe and
- Heidi May
Heart failure (HF), which is often subdivided according to baseline left ventricular ejection fraction (LVEF), remains a major cause of morbidity and mortality throughout the world. Although HF with reduced LVEF (HFrEF), when compared with preserved LVEF (HFpEF), is often considered to be more fatal, the real-world relative incidence and long-term risk associated with each remains unclear.
Between 1/1/2003 and 12/3/2018, 35,135 Intermountain Healthcare patients, ≥18 years of age, with a clinical diagnosis of HF and at least one documented LVEF, were identified. Baseline clinical characteristics were collected, and patients were stratified into three groups according to their baseline LVEF: ≤35% = HFrEF; 36-50% = HF with intermediate LVEF (HFiEF); >50% = HFpEF. Patients were followed for an average of five years for future major adverse cardiovascular events (MACE) including death, myocardial infarction (MI) and heart failure hospitalization (HFH). Differences between categories were identified by multivariable Cox regression analysis.
Baseline characteristics, and incidence of future cardiovascular events, according to LVEF category, are shown in the Table.
In this large, modern, real-world HF population, the 5-year incidence of adverse cardiovascular events remains high regardless of baseline LVEF. However, after multivariable adjustment, HFrEF is associated with a higher incidence of death and HF hospitalization than either HFpEF or HFiEF.
Posters Hall_Hall A
Sunday, March 29, 2020, 12:30 p.m.-1:15 p.m.
Session Title: Heart Failure and Cardiomyopathies: Clinical 5
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1308-070
- 2020 American College of Cardiology Foundation