Author + information
- Priya P. Mehta,
- Laura Colangelo,
- Abbi Lane-Cordova,
- Amanda M. Perak,
- Philip Greenland,
- William Grobman,
- Sanjiv Shah,
- Mercedes Carnethon,
- Janet Catov,
- Norrina Allen,
- Erica P. Gunderson and
- Sadiya Khan
Adverse pregnancy outcomes (APO) are associated with increased maternal risk of heart failure (HF). We investigated whether adverse cardiac mechanics, which precede HF, are present after an APO.
We included women from the CARDIA study who had ≥1 live birth and completed an echocardiogram at year 30 (Y30). We excluded women with a pre-pregnancy history of diabetes or hypertension or those who developed HF. Self-report of APO included preeclampsia, gestational hypertension, pre-term birth (<37 weeks gestation), and low birth weight (<2500 grams). We performed linear regression to examine the association between APO and cardiac mechanics. In separate multivariable models, we adjusted for pre-pregnancy and post-pregnancy risk factors (RF).
Of 936 women, 47% were black and mean age at Y0 was 24.3±3.6 years. 330 (35%) women reported at least one APO over 1.8±0.9 births. At Y30, women who experienced an APO had higher RF levels, including higher body mass index and blood pressure. After adjustment for pre-pregnancy or Y30 RF, GLS remained significantly lower in women who experienced a low birth weight pregnancy (Table). Modifiable RF attenuated the relationship between APO and GLS in the other APO subtypes.
Approximately 1 in 3 women reported a history of an APO, highlighting the importance of targeting RF in young women of reproductive age, particular following an APO. Pregnancies complicated by low birth weight may be an independent sex-specific risk factor for HF.
Posters Hall_Hall A
Monday, March 30, 2020, 9:45 a.m.-10:30 a.m.
Session Title: Prevention: Clinical 7
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1420-086
- 2020 American College of Cardiology Foundation