Author + information
- Ramin Ebrahimi,
- Jennifer Sumner,
- Jean Beckham,
- Kristine Lynch,
- Paul Dennis,
- Chi-Hong Tseng,
- Gregorio Coronado,
- Benjamin Viernes and
- Laurie Shroyer
Posttraumatic stress disorder (PTSD) is associated with ischemic heart disease (IHD) in men. Despite sex differences in the prevalence and pathophysiology of PTSD and IHD, research on this association in women is limited. The goal of this study was to evaluate the association of PTSD with IHD in women veterans.
This cross-sectional study used data from the Department of Veterans Affairs (VA) nationwide corporate data warehouse to identify women veterans visiting any of the VA medical centers between fiscal year (FY) 2000 and FY2017. International Classification of Disease codes were used to identify patients with PTSD and IHD (coronary artery disease, unstable angina, myocardial infarction). After comparison of unadjusted data, serial adjustments were made to account for age, traditional IHD risk factors, obesity and chronic kidney disease (CKD), female specific risk factors (gestational diabetes and hypertension, placental syndromes) and psychiatric disorders, alcohol and illicit drug dependence.
Between FY2000 to FY2017, 835,197 women veterans with an average age of 50.4 years visited the VA. 151,144 (18.1%) had PTSD and 684,053 (81.9%) did not have PTSD. Women with PTSD had increased hazard ratio (HR) for IHD (1.20, p %<0.0001). This increased hazard ratio remained significant after adjustment for age (1.95, p%<0.0001), IHD risk factors (1.59, p %<0.0001), obesity and CKD (1.48, p%<0.0001), female specific risk factors (1.48 p %<0.0001) and psychiatric, alcohol and illicit drug dependence (1.21 p%<0.0001).
In this largest study of association of PTSD with IHD ever conducted, after adjustment for age, IHD risk factors, obesity, CKD, psychiatric disorders, alcohol and illicit drug dependence, PTSD was associated with significantly increased risk of IHD in women veteran. Given the growing number of women veterans, these findings can have practice implications for early and routine IHD screening in this high-risk population.
Moderated Poster Contributions
Prevention Moderated Poster Theater, Posters, Hall A
Saturday, March 28, 2020, 11:15 a.m.-11:25 a.m.
Session Title: How Can a “Learning Health Care System” Inform Cardiovascular Prevention Community?
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1006-13
- 2020 American College of Cardiology Foundation