Author + information
- Manish Gupta,
- Muhammad Umair Bakhsh and
- Kamesh Gupta
Cardiovascular disease remains the number 1 cause of death in the US. Coronary artery disease alone accounted for approximately 13% deaths in the US in 2016. Some studies have suggested an increased prevalence of CAD in chronic inflammatory conditions such as celiac disease (CD). Chronic subclinical systemic inflammation decreased absorption of cardio-protective nutrients and drugs have been postulated as the pivotal mechanisms for increased risk of CAD.
We reviewed Nationwide Inpatient Sample from 2005-2014 for adult acute myocardial infarction (AMI) as a principal diagnosis with CD as the secondary diagnosis by using validated ICD9-CM codes. We examined the annual trends in the number of cases and hospitalization charges yearly and used survey regression to calculate adjusted odds ratios (aOR) for hospital mortality and other outcomes.
We identified a total of 61,80,485 AMI hospitalizations from 2005-2014 of which 3169 had a diagnosis for CD. The proportion of patients with CD in AMI hospitalizations increased from 0.015% in 2005 to 0.076% in 2014. CD+AMI patients were significantly older (70.3 vs. 67.4 years, p< 0.02), more likely female (51.9% vs. 39.5%, p value %<0.01), white (93.8% vs. 76.6%; p< 0.01). After adjusting for age, gender, race, Charlson Comorbidity index and hospital level characteristics, CD+AMI hospitalizations had lower odds-ratio for hospital mortality (aOR=0.39; 95% CI= 0.23-0.67; p< 0.01). Length of stay in the CD+AMI patients was shorter (4.53 vs 4.84 days, p< 0.01) but the mean hospitalization charges were higher ($64058 vs $60223, p< 0.01), as compared to non-CD AMI patients.
We found that the number of acute myocardial infarction related admissions in the CD patients has risen more than five-fold from 2005-2014. However, the odd of in-hospital mortality in these patients is lower than the patients without CD for unclear reasons or mechanisms. The results of our study shows that though the CD-related systemic inflammation is associated with an increasing number of AMI hospitalizations, these patients have comparatively favorable outcomes than controls; though it definitely adds an extra cost to the hospitalization.
Posters Hall_Hall A
Saturday, March 28, 2020, 12:30 p.m.-1:15 p.m.
Session Title: Acute and Stable Ischemic Heart Disease: Clinical 2
Abstract Category: 02. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1163-191
- 2020 American College of Cardiology Foundation