Author + information
- Muhammad Khan,
- Kenneth Ellenbogen,
- Krunalkumar Patel,
- Sona Franklin,
- Do Young Kim,
- Umang Patel and
- Steven P. Kutalek
Studies have shown that the incidence of atrial fibrillation (Afib) in cancer is most likely due to the presence of inflammatory markers. Certain cancers release more systemic inflammatory markers. The purpose of our study is to determine whether cancers with greater inflammatory markers lead to higher incidence of Afib compared to others, and their impact on mortality.
Data were obtained from National Inpatient Sample database between 2012-2015. Patients with various cancers and Afib were studied. Statistical analysis was performed using Pearson chi-square and binary logistic regression analysis to determine the association of individual cancers with Afib. ICD-9-CM codes were utilized to verify variables. Analysis was performed with SAS.
Incidence of Afib was 10.12% among total study patients (n=143,211,398). Patients with Afib had a statistically significant (p=0.001) association between prostate (3.60%), lung (2.78%), colon (2.27%), breast (3.31%), pancreas (0.28%), leukemia (0.98%), non Hodgkins (1.18%), Hodgkins (0.10%) and thoracic (0.03%). When adjusting for hypertension, diabetes, coronary artery disease, cardiomyopathy, valvular disorder, thyrotoxicosis, the odds of having Afib with any cancer (2.35) prostate (1.63), lung (1.6), colon (1.53), breast (1.43), pancreas (0.94), leukemia (1.34), non Hodgkins (1.44), Hodgkins (0.92), thoracic (1.44). No significant association was found between thyroid carcinoma and Afib. There was a higher mortality in patients with Afib and prostate cancer (2.31 vs 3.28%), Non-Hodgkins lymphoma (1.61 vs 1.64%) and colon cancer (2.2 vs 2.46%) (p=%<0.001).
Patients who have prostate cancer have the highest incidence of Afib compared to other types of cancer. Our study found that there is a 2.3-fold increased odds of having Afib with all cancers studied. There was 50% increased risk of Afib in colon, prostate, and lung cancer patients. There was a higher mortality associated with Afib and prostate cancer, Non-Hodgkins lymphoma and colon cancer.
Posters Hall_Hall A
Saturday, March 28, 2020, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Basic 3
Abstract Category: 04. Arrhythmias and Clinical EP: Basic
Presentation Number: 1216-235
- 2020 American College of Cardiology Foundation