Author + information
- Daniel A. Gerber,
- Marcia Stefanick,
- Mark Hlatky,
- Jaden Yang,
- Haley Hedlin,
- Bernhard Haring and
- Marco Perez
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with significant morbidity and mortality. Despite well-documented associations between protein intake, coronary disease, and stroke, the relationship between protein intake and AF has not been explored.
This was a secondary analysis of postmenopausal women from the Women's Health Initiative Randomized Controlled Trials and Observational Study. Women with baseline AF and missing data were excluded. Incident AF was identified by Medicare claims diagnosis codes. Protein intake was derived from food questionnaires and calibrated by the previously validated Nutritional Biomarkers Study urinary nitrogen protocol. Physical activity was assessed by self report. Multivariate Cox proportional hazard regression analysis were used to evaluate the association between calibrated protein intake and incident AF adjusted for age, ethnicity, education, physical activity, BMI, tobacco and alcohol use, hypertension, hyperlipidemia, diabetes, coronary and peripheral artery disease, and heart failure. Interaction analyses between protein intake and physical activity in their association with AF were performed.
The analytic cohort included 99,554 women. Median age was 64.0 years with 8.3% Black, 2.9% Hispanic, and 2.2% Asian. Incident AF was identified in 21,258 women (21.3%) over a 10.1 year average follow up. Median protein intake was 66 grams (g)/day. Compared to the lowest protein quartile (<58 g/day), women in the second (58-66 g/day; HR 0.932, p=0.001) and third quartiles (66-74 g/day; HR 0.908, p=0.0005) had a significantly lower AF risk. This benefit was no longer statistically significant in the highest protein quartile (>74 g/day; HR 0.951, p=0.186). Physical activity did not significantly modify the effect of protein intake on incident AF.
Protein consumption of 58-74 g/day, which is higher than the current Recommended Dietary Allowance, was associated with a reduction in AF risk compared to lower protein intake. These effects were mitigated at consumption >74 g/day. This association was observed across all levels of physical activity.
Moderated Poster Contributions
Arrhythmias and Clinical EP Moderated Poster Theater, Posters, Hall A
Sunday, March 29, 2020, 3:45 p.m.-3:55 p.m.
Session Title: Differential Gender Outcomes in Arrhythmia Management
Abstract Category: 08. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1061-03
- 2020 American College of Cardiology Foundation