Cognitive Trajectories in Global Cognition and Different Domains by Framingham General Cardiovascular Risk Score in Tertiles
Trajectories represent β-coefficients from linear mixed-effects models adjusted for age, sex, education, body mass index, stroke, heart disease, alcohol consumption, physical activity, and APOE ε4, with the lowest risk as reference group. The y-axes represent z-scores of composite scores, which represent the global cognitive function and 5 cognitive domains. This figure shows follow-up time-related cognitive trajectories in global cognition and different domains. Compared with the lowest tertile of the Framingham General Cardiovascular Risk Score, the highest was associated with faster decline in global cognition (β = –0.019; 95% CI: –0.035 to –0.003), episodic memory (β = –0.023; 95% CI: –0.041 to –0.004), working memory (β = –0.021; 95% CI: –0.035 to –0.007), and perceptual speed (β = –0.027; 95% CI: –0.042 to –0.011) over the follow-up. APOE = apolipoprotein E; CI = confidence interval.