|Indication||Patient Characteristics That May Further Increase Thrombotic Risk|
|Mechanical valve prosthesis with or without AF∗|
|Valvular AF (with moderate or greater mitral stenosis or a mechanical valve prosthesis)∗|
|Prior thromboembolism with interruption of anticoagulation|
|Left ventricular thrombus§|
|Left atrial thrombus|
|Left ventricular assist device§|
AF = atrial fibrillation; CHA2DS2-VASc = Congestive heart failure, Hypertension, Age (>65 = 1 point, ≥75 = 2 points), Diabetes, previous Stroke/transient ischemic attack (2 points); HF = heart failure; LV = left ventricular; MI = myocardial infarction; TIA = transient ischemic attack; VTE = venous thromboembolism.
↵∗ Currently, only warfarin is indicated for patients ready to restart their anticoagulation.
↵† Patients can resume any OAC when ready to restart their anticoagulation.
↵‡ For patients with CHA2DS2-VASc scores of 4, the annual rate of thromboembolism is 4% (2.8%–5.4%) (96).
↵§ Currently, only conventional-intensity warfarin therapy is indicated for patients ready to restart their anticoagulation.